APIM High Availability and Performance across Regions

Overview:  APIM can be setup in multiple regions and incoming request will be routed to the closest APIM endpoint.  If there is only 1 APIM region, it is best to ensure the API/App Service/Function is hosted in the same region.  With multiple APIM's you can also host a API in the same region.  The routing is either done automatically using Azure Front Door or via policy on the APIM.

More Info: 

https://docs.microsoft.com/en-us/azure/api-management/api-management-howto-deploy-multi-region